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Silylation with MBDSTFA
Summary
Type: GCApplication #: 213113
Catalog#: 701440.101 - MBDSTFA. 10x1 ml
Detection: GC; especially for GC-MS
Conditions: Silylation reagent which donates a tert-butyldimethylsilyl group (TBDMS) for derivatising active hydrogen atoms in hydroxyl, carboxyl and thiol groups as well as primary and secondary amines.
It shows a fast reactions (typically 5 – 20 min) with high yields (> 96%). By-products are neutral and volatile.
TBDMS ethers are more stable than the corresponding TMS ethers.
Chromatographic retention times are longer due to the large protecting group, which may improve some separations. Because of the high molecular ion concentration at M+-57 it is useful for GC-MS applications.
Authors: Macherey-Nagel
Source: GC department (2007)
Details
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