104880 Determination of diltiazem and its metabolites in plasma by HPLC

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Determination of diltiazem and its metabolites in plasma by HPLC

Summary

Type: HPLC
Application #: 104880
Catalog#: 720949.46 - MN HPLC Column, Nucleosil C18, 100A, 3um, 4.6x150mm
Detection: UV, 237nm
Conditions: eluent: acetonitrile - 0.1mol/l ammonium dihydrogen phosphate buffer (37:63, v/v), containing 0.06% triethylamine, pH adjusted to 5.9 with o-phosphoric acid
flow rate 1ml/min
Authors: Boulieu R
Source: J Liquid Chromatogr 13 (1990) 291 - 301


Details


Legend: Fig. 2. Chromatographic separation of diltiazem and its metabolites, 1. N-demethyldeacetyldiltiazem (M2), 2. deacetyldiltiazem (M1), 3. N-demethyldiltiazem (MA), 4. diltiazem, 5. propionyl-deacetyl