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HPLC determination of navelbine in human plasma and urine
Summary
Type: HPLCApplication #: 104470
Catalog#: 720120.46 - MN HPLC Column, Nucleosil C18, 100A, 5um, 4.6x150mm
Detection: amperometric, glassy carbon electrode 0.93V versus Ag/AgCl
Conditions: eluent: acetonitrile - methanol - 0.1% (w/v) aqueous NaH2PO4 containing 0.4g/l heptanesulphonate and 0.3g/l EDTA, adjusted to pH 3 with 1M phosphoric acid (8:50:42, v/v)
flow rate 1.1ml/min
Authors: Nicot G
Source: J Chromatogr 528 (1990) 258 - 266
Details
Legend: Fig. 1. Chromatograms of extracts from A) blank (pre-dose) patient plasma, B) plasma sample obtained from a patient 2h after receiving a 30mg/m2 infusion of navelbine, containing 110ng/ml (6.76min)