104130 Ion-exchange HPLC in drug assay in biological fluids V. Propranolol and metabolites

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Ion-exchange HPLC in drug assay in biological fluids V. Propranolol and metabolites

Summary

Type: HPLC
Application #: 104130
Catalog#: 720097.40 - MN HPLC Column, Nucleosil SA, 100A, 5um, 4x250mm
Detection: fluorescence, excitation 225nm, emission 350nm
Conditions: eluent: acetonitrile - water - diethylamine - H3PO4 (156:300:1.9:1.55, v/v)
flow rate 1.5ml/min
Authors: Belolipetskaja VG
Source: J Chromatogr 491 (1989) 507 - 512


Details


Legend: Fig. 1. Chromatograms of propranolol and its metabolites in serum taken from patients A) before and B) after drug administration, 1. 4-hydroxypropranolol sulphate, 2. S-propranolol glucuronide, 3. R