103960 HPLC of a 2-amino-2-oxazoline: application to pharmacokinetic studies in dogs

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HPLC of a 2-amino-2-oxazoline: application to pharmacokinetic studies in dogs

Summary

Type: HPLC
Application #: 103960
Detection: UV, 235nm
Conditions: eluent: methanol - 0.1M ammonium acetate (5:95, v/v) containing 2mM Na heptanesulphonate, 1% tetrahydrofuran and 0.2% triethylamine, pH adjusted to 4.5 with H3PO4
flow rate 1ml/min
Authors: Damaj MI
Source: J Pharm Sci 79 (1990) 516 - 518


Details


Legend: Fig. 1. Chromatograms of A) blank plasma, B) plasma spiked with 125µg/l COR3224, C) plasma spiked with 1000µg/l COR3224, 1. COR3224, 2. ortho-O-methyl derivative of 1. (int. std.).