103890 HPLC method for the determination of amineptine and its main metabolite in human plasma

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HPLC method for the determination of amineptine and its main metabolite in human plasma

Summary

Type: HPLC
Application #: 103890
Catalog#: 720120.46 - MN HPLC Column, Nucleosil C18, 100A, 5um, 4.6x150mm
Detection: UV 220nm
Conditions: aqueous phase containing 1.2g/l heptanesulphonate adjusted to pH 3.0 with H3PO4 - acetonitrile (62:38, v/v)
Authors: Nicot G
Source: J Chromatogr 306 (1984) 279 - 290


Details


Legend: Chromatograms of extracts from a) blank plasma, b) plasma spiked with 250ng/ml metabolite (1), 250ng/ml amineptine (2), and 500ng/ml internal standard (3), c) a patient plasma sample obtained 45min