103780 Identification and determination of the two principal metabolites of minocycline in humans

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Identification and determination of the two principal metabolites of minocycline in humans

Summary

Type: HPLC
Application #: 103780
Catalog#: 720023.46 - MN HPLC Column, Nucleosil C18, 100A, 10um, 4.6x250mm
Detection: UV, 352nm
Conditions: eluent: gradient from 10 to 40% acetonitrile in 0.2% formic acid within 5min, then 8μin 40% acetonitrile
flow rate 1.2ml/min
Authors: Böcker R H
Source: J Chromatogr 568 (1991) 363 - 374


Details


Legend: Fig. 1. HPLC determination of minocycline in human serum and urine, A) blank serum spiked with 1µg/ml minocycline, B) serum at 0.5h, C) serum at 1.5h, D) serum at 24h, E) urine at 0 - 12h, F) urine