103770 Analysis and quantitation of a metabolite of doxycycline in mice rats and humans by HPLC

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Analysis and quantitation of a metabolite of doxycycline in mice rats and humans by HPLC

Summary

Type: HPLC
Application #: 103770
Catalog#: 720022.40 - MN HPLC Column, Nucleosil C8, 100A, 10um, 4x250mm
Detection: UV, A) and B) 344nm, C) and D) 370nm
Conditions: eluent: 3.5mmol/l aqueous NaH2PO4 - acetonitrile (70:30), pH 2.7
flow rate 1.9ml/min
Authors: Böcker R H
Source: J Chromatogr 274 (1983) 255 - 262


Details


Legend: Fig. 1. Chromatographic analysis of doxycycline and its metabolite, A) liver extract of a control mouse, 6h after intravenous application of 50µg/g doxycycline, B) liver extract of a phenobarbital p