103640 Determination of clarithromycin and non-polar impurities in dosage forms and bulk drug by HPLC

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Determination of clarithromycin and non-polar impurities in dosage forms and bulk drug by HPLC

Summary

Type: HPLC
Application #: 103640
Catalog#: 720120.46 - MN HPLC Column, Nucleosil C18, 100A, 5um, 4.6x150mm
Detection: upper Fig. 2: UV, 210nm lower Fig. 2: UV, 205nm
Conditions: upper Fig. 2: temperature 50°C
eluent: methanol - 0.067M KH2PO4 (60:40)
flow rate 1ml/min
lower Fig. 2: Column: NUCLEOSIL® 100-5C18, 150 x 4.6mm ID
eluent: flow rate 1ml/min
Authors: Morgan DK
Source: J Pharm Biomed Anal 9 (1991) 261 - 269


Details


Legend: Fig. 2. (upper fig.) Chromatogram of a blank and a working standard solution of clarithromycin, using biphenyl as internal standard. Fig. 2. (lower fig.) Chromatogram of non-polar compounds observ